Subthalamic deep brain stimulation and impulse control in Parkinson’s disease
Identifieur interne : 000904 ( Main/Corpus ); précédent : 000903; suivant : 000905Subthalamic deep brain stimulation and impulse control in Parkinson’s disease
Auteurs : T. D. H Lbig ; W. Tse ; P. G. Frisina ; B. R. Baker ; E. Hollander ; H. Shapiro ; M. Tagliati ; W. C. Koller ; C. W. OlanowSource :
- European Journal of Neurology [ 1351-5101 ] ; 2009-04.
English descriptors
Abstract
Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory. Results: Independent samples t‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.
Url:
DOI: 10.1111/j.1468-1331.2008.02509.x
Links to Exploration step
ISTEX:C8C319092C78175CF614582D1027F645DF253473Le document en format XML
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Frisina</name><affiliation><mods:affiliation>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Baker, B R" sort="Baker, B R" uniqKey="Baker B" first="B. R." last="Baker">B. R. Baker</name><affiliation><mods:affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Hollander, E" sort="Hollander, E" uniqKey="Hollander E" first="E." last="Hollander">E. Hollander</name><affiliation><mods:affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Shapiro, H" sort="Shapiro, H" uniqKey="Shapiro H" first="H." last="Shapiro">H. Shapiro</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Tagliati, M" sort="Tagliati, M" uniqKey="Tagliati M" first="M." last="Tagliati">M. Tagliati</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Olanow, C W" sort="Olanow, C W" uniqKey="Olanow C" first="C. W." last="Olanow">C. W. 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H Lbig</name><affiliation><mods:affiliation>Fédération de Neurologie, Centre Hospitalier Universitaire Pitié‐Salpêtrière, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Tse, W" sort="Tse, W" uniqKey="Tse W" first="W." last="Tse">W. Tse</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Frisina, P G" sort="Frisina, P G" uniqKey="Frisina P" first="P. G." last="Frisina">P. G. Frisina</name><affiliation><mods:affiliation>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Baker, B R" sort="Baker, B R" uniqKey="Baker B" first="B. R." last="Baker">B. R. Baker</name><affiliation><mods:affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Hollander, E" sort="Hollander, E" uniqKey="Hollander E" first="E." last="Hollander">E. Hollander</name><affiliation><mods:affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Shapiro, H" sort="Shapiro, H" uniqKey="Shapiro H" first="H." last="Shapiro">H. Shapiro</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Tagliati, M" sort="Tagliati, M" uniqKey="Tagliati M" first="M." last="Tagliati">M. Tagliati</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W. C." last="Koller">W. C. Koller</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author><author><name sortKey="Olanow, C W" sort="Olanow, C W" uniqKey="Olanow C" first="C. W." last="Olanow">C. W. Olanow</name><affiliation><mods:affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-04">2009-04</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="493">493</biblScope><biblScope unit="page" to="497">497</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">C8C319092C78175CF614582D1027F645DF253473</idno><idno type="DOI">10.1111/j.1468-1331.2008.02509.x</idno><idno type="ArticleID">ENE2509</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>deep brain stimulation</term><term>impulsivity</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory. Results: Independent samples t‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>T. D. Hälbig</name><affiliations><json:string>Fédération de Neurologie, Centre Hospitalier Universitaire Pitié‐Salpêtrière, Paris, France</json:string><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>W. Tse</name><affiliations><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>P. G. Frisina</name><affiliations><json:string>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</json:string></affiliations></json:item><json:item><name>B. R. Baker</name><affiliations><json:string>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>E. Hollander</name><affiliations><json:string>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>H. Shapiro</name><affiliations><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>M. Tagliati</name><affiliations><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>W. C. Koller</name><affiliations><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item><json:item><name>C. W. Olanow</name><affiliations><json:string>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>impulsivity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson’s disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item></subject><articleId><json:string>ENE2509</json:string></articleId><language><json:string>eng</json:string></language><abstract>Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory. Results: Independent samples t‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.</abstract><qualityIndicators><score>5.785</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1420</abstractCharCount><pdfWordCount>3349</pdfWordCount><pdfCharCount>21730</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>203</abstractWordCount></qualityIndicators><title>Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title><genre><json:string>article</json:string></genre><host><volume>16</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>5</total><last>497</last><first>493</first></pages><issn><json:string>1351-5101</json:string></issn><issue>4</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1111/j.1468-1331.2008.02509.x</json:string></doi><id>C8C319092C78175CF614582D1027F645DF253473</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/C8C319092C78175CF614582D1027F645DF253473/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/C8C319092C78175CF614582D1027F645DF253473/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C8C319092C78175CF614582D1027F645DF253473/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title><author><persName><forename type="first">T. D.</forename><surname>Hälbig</surname></persName><affiliation>Fédération de Neurologie, Centre Hospitalier Universitaire Pitié‐Salpêtrière, Paris, France</affiliation><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">W.</forename><surname>Tse</surname></persName><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">P. G.</forename><surname>Frisina</surname></persName><affiliation>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</affiliation></author><author><persName><forename type="first">B. R.</forename><surname>Baker</surname></persName><affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">E.</forename><surname>Hollander</surname></persName><affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">H.</forename><surname>Shapiro</surname></persName><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">M.</forename><surname>Tagliati</surname></persName><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">W. C.</forename><surname>Koller</surname></persName><note type="biography">Deceased.</note><affiliation>Deceased.</affiliation><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author><author><persName><forename type="first">C. W.</forename><surname>Olanow</surname></persName><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-04"></date><biblScope unit="volume">16</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="493">493</biblScope><biblScope unit="page" to="497">497</biblScope></imprint></monogr><idno type="istex">C8C319092C78175CF614582D1027F645DF253473</idno><idno type="DOI">10.1111/j.1468-1331.2008.02509.x</idno><idno type="ArticleID">ENE2509</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory. Results: Independent samples t‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>deep brain stimulation</term></item><item><term>impulsivity</term></item><item><term>Parkinson’s disease</term></item><item><term>subthalamic nucleus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/C8C319092C78175CF614582D1027F645DF253473/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/ene.2009.16.issue-4</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2009-04">April 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="14" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02509.x</doi><idGroup><id type="unit" value="ENE2509"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2009 The Author(s). Journal compilation © 2009 EFNS</copyright><eventGroup><event type="firstOnline" date="2009-02-19"></event><event type="publishedOnlineFinalForm" date="2009-03-19"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="493">493</numbering><numbering type="pageLast" number="497">497</numbering></numberingGroup><correspondenceTo>Thomas D. Hälbig, MD, Fédération de Neurologie & Centre d’Investigation Clinique, Centre Hospitalier Universitaire Pitié‐Salpêtrière, 47‐83 Boulevard de l’Hôpital, 75651 Paris cedex 13, France (tel.: +33 1 42 16 19 50; fax: +33 1 42 16 19 58; e‐mail: <email>halbig.psl@gmail.com</email>; <email>thomas.halbig@psl.aphp.fr</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2509.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 26 September 2008 Accepted 20 October 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title><title type="shortAuthors">T. D. Hälbig <i>et al.</i></title><title type="short">Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>T. D.</givenNames><familyName>Hälbig</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>W.</givenNames><familyName>Tse</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>P. G.</givenNames><familyName>Frisina</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>B. R.</givenNames><familyName>Baker</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>E.</givenNames><familyName>Hollander</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>H.</givenNames><familyName>Shapiro</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>M.</givenNames><familyName>Tagliati</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a2" noteRef="#fn1"><personName><givenNames>W. C.</givenNames><familyName>Koller</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a2"><personName><givenNames>C. W.</givenNames><familyName>Olanow</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Fédération de Neurologie, Centre Hospitalier Universitaire Pitié‐Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="US"><unparsedAffiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">deep brain stimulation</keyword><keyword xml:id="k2">impulsivity</keyword><keyword xml:id="k3">Parkinson’s disease</keyword><keyword xml:id="k4">subthalamic nucleus</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background and purpose: </b> Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson<b>’</b>s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy.</p><p><b>Methods: </b> In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory.</p><p><b>Results: </b> Independent samples <i>t</i>‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients.</p><p><b>Conclusions: </b> Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p> Deceased.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthalamic deep brain stimulation and impulse control in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">T. D.</namePart><namePart type="family">Hälbig</namePart><affiliation>Fédération de Neurologie, Centre Hospitalier Universitaire Pitié‐Salpêtrière, Paris, France</affiliation><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Tse</namePart><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. G.</namePart><namePart type="family">Frisina</namePart><affiliation>Department of Geriatrics, Mount Sinai School of Medicine, & The Jewish Home & Hospital Lifecare System, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. R.</namePart><namePart type="family">Baker</namePart><affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Hollander</namePart><affiliation>Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Shapiro</namePart><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Tagliati</namePart><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. C.</namePart><namePart type="family">Koller</namePart><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><description>Deceased.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Olanow</namePart><affiliation>Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-04</dateIssued><edition>Received 26 September 2008 Accepted 20 October 2008</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent></physicalDescription><abstract lang="en">Background and purpose: Experimental studies suggest that deep brain stimulation (DBS) of the subthalamic nucleus (STN) induces impulsivity in patients with Parkinson’s disease (PD). The purpose of this study was to assess various measures of impulse control in PD patients with STN DBS in comparison to patients receiving medical therapy. Methods: In a cross‐sectional evaluation, 53 consecutively eligible patients were assessed for impulsivity with the Barratt Impulsiveness Scale, for impulse control disorders (ICDs) using the Minnesota Impulsive Disorders Interview, and for obsessive–compulsive symptoms using the Maudsley Obsessional‐Compulsive Inventory. Results: Independent samples t‐tests revealed that compulsivity scores were not different between DBS patients and patients without DBS. However, impulsivity scores were significantly higher in DBS patients. Additionally, ICDs were observed in 3 of 16 (19%) DBS patients and in 3 of 37 (8%) medically treated patients. No association was found between the use of dopamine agonists and impulsivity in DBS patients. Conclusions: Our data suggest that screening for impulsivity and ICDs should be performed prior to DBS, and that patients should be monitored for these problems during follow‐up. Prospective trials are needed to confirm the findings of this exploratory study and to elucidate the reasons of a possible induction of impulsivity by STN DBS.</abstract><subject lang="en"><genre>Keywords</genre><topic>deep brain stimulation</topic><topic>impulsivity</topic><topic>Parkinson’s disease</topic><topic>subthalamic nucleus</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>493</start><end>497</end><total>5</total></extent></part></relatedItem><identifier type="istex">C8C319092C78175CF614582D1027F645DF253473</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02509.x</identifier><identifier type="ArticleID">ENE2509</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2009 The Author(s). 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